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Garbe's team confirmed this peptide's presence in the sweat of four people.At that point, the investigators suspected that their mysterious peptide might be a microbe killer, even though its structure differs considerably from defensins and cathelicidins, the two known classes of michael kors handbags clearance antimicrobial peptides. They verified their suspicion by demonstrating in test tube experiments that dermicidin can kill four different kinds of bacteria and one fungal species.The investigators also showed that the peptide retains its killing capability in solutions whose acidity mulberry outlet york and salt content resemble sweat; other antimicrobial peptides don't function well or at all in such conditions.A major remaining question is how dermicidin destroys microbes, says Garbe's colleague Birgit Schittek. Other germ killing peptides, which have positive charges, are drawn to louboutin uk and punch holes through the negatively charged membranes of microbes.
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