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The Drosophila lethal(3)malignant brain tumor (D l(3)mbt) gene is reported to be one of the tumor suppressor genes of Drosophila melanogaster, and its recessive mutations are associated with malignant transformation of the neuroblasts and ganglion mother cells in the presumptive adult optic centers in mulberry outlet online the larval brain (Gateff et al., 1993; Wismar et al., 1995). The predicted amino acid sequences of D l(3)mbt protein reveal that it contains three distinct domains: a C2/C2 type zinc finger domain, three repeat units called mbt repeats' each about 100 amino acids in length, and a C terminal helical segment cheap moncler comprised of an approximately 60 amino acid motif termed the SPM (Scm, ph, mbt) domain (Bornemann et al., 1996; Wismar et al., 1995). However, any characteristics of the D l(3)mbt protein such as tissue distribution, subcellular localization, functions of the mbt repeats and the SPM domain, have not yet been louboutin pas cher identified.
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