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Received 25 March 2010; Revised 25 September 2010; Accepted 27 September 2010; Published online 25 November 2010.Top of pageAbstractThe transcription factor Forkhead box O3 (Foxo3) has a critical cheap louboutins role in suppressing the expansion of antigen specific effector T cell populations; hence, Foxo3 is a potential target for enhancing the antitumor immunity of cancer vaccines. In this report, we evaluated the potential of RNA interference (RNAi) mediated silencing of Foxo3 in antigen presenting cells as an adjuvant for HER2 DNA cancer louboutin shoes outlet vaccines. Bicistronic plasmids expressing the N terminal extracellular domain of human HER 2 and the Foxo3 short hairpin RNA (hN shRNA) or the scrambled control (hN shRNA) were subcutaneously injected into mice by gene gun administration to elicit antitumor immunity against p185neu overexpressing MBT 2 bladder tumor cells.JXM.9.17


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