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Collectively, YP2 induced CPE was evident in HER 2/neu overexpressing cells, including human bladder, mouse bladder, sac a main longchamp pas cher and hamster oral cancer cells. Nevertheless, CPE was observed neither in NIH3T3 fibroblasts nor in bladder cancer cells with lower or negligible levels of HER 2/neu expression, such as TCC SUP and J82 cells. (a) CPE in MBT 2 cells infected with YP2 or TNL, but not CW1.
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(b) Kaplan survival curves at day 50 are shown (P=0.0028 for YP2 vs CW1 and P=0.0022 for YP2 vs PBS by the log rank test). (c) Detection of PrV proteins within MBT 2 tumors in vivo. C3H/HeN mice bearing MBT 2 tumors louboutin outlet uk were injected intratumorally with 2 106 TCID50 of YP2 or TNL, or PBS for 3 consecutive days.
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