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Mutations made in the aromatic cage of the second MBT domain (D381A) and in the aromatic cage of the first MBT domain (D274A) are represented by stars. A schematic of all protein constructs and tagged fusion proteins used for in vitro and cellular studies is in Supplementary Figure 21. (d) A surface representation air max pas cher femme of the 3MBT crystal structure (PDB code 3UT1), colored as in c, with the residues composing the conserved (domain 2) or semiconserved (domains 1 and 3) aromatic ...