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The effects of T cell depletion on therapeutic efficacyTo determine if CD4+ and CD8+ T cells were required for therapeutic efficacy, we depleted CD4+ or CD8+ T cells with monoclonal antibodies (mAbs) specific for CD4 or CD8, respectively. Depletions were performed at weekly intervals (Figure 4a). Depletion christian louboutin outlet uk of CD8+ T cells significantly impaired, but did not completely abolish, the therapeutic efficacy of GA plus N' neu DNA vaccination (Figure 4b).
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