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Moreover, endogenous NLRC5 localized to the nucleus and occupied the proximal promoter region of H 2 genes. Consistent with downregulated MHC I expression, the elimination of Nlrc5 lymphocytes by cytotoxic T cells was markedly reduced and, in addition, we observed low NLRC5 expression in several murine and human lymphoid derived tumor cell cheap moncler jackets lines. Hence, loss of NLRC5 expression represents an advantage for evading CD8+ T cell mediated elimination by downmodulation of MHC I levels ...

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