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Moreover, endogenous NLRC5 localized to the nucleus and occupied the proximal promoter region of H 2 genes. Consistent with downregulated MHC I expression, the elimination of Nlrc5 lymphocytes by cytotoxic T cells was markedly reduced and, in addition, we observed low NLRC5 expression in several murine and human lymphoid derived tumor cell cheap moncler jackets lines. Hence, loss of NLRC5 expression represents an advantage for evading CD8+ T cell mediated elimination by downmodulation of MHC I levels mechanism that may be exploited by transformed cells.
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Is the storm overhyped? Could it still miss us like some snowstorms do? Models have come into solid agreement on Sandy's general track and strength. So our confidence in the forecast is relatively high compared to some of the trickier mulberry outlet online snowstorms we seen in the past. Small changes in track could give us less rain and weaker winds than we expecting.
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